Anti-PanK4 (Thr63) Antibody

Our Anti-PanK4 (Thr63) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse PanK4 (Thr63) and is antigen affinity purified from pooled serum. It is great for use in WB.

Product Specifications

Background

Pantothenate kinase, PanK, is a vital regulatory enzyme for coenzyme A (CoA) biosynthesis, phosphorylating pantothenate (vitamin B5) to 4’-phosphopantothenate, then quickly transforming to CoA which is an essential component for fatty acid metabolism (Abiko, Y, 1967) . There are 4 members of the PanK family, located on chromosomes 10q23.31, 20p13, 5q35, and 1p36.32 (Zhou et al, 2001) . PanK1 is predominantly in heart, liver, and kidney. PanK2 is expressed ubiquitously, with higher levels in retinal and infant basal ganglia. PanK3 has high levels in liver, while PanK4 is expressed ubiquitously with its highest levels found in muscle (Zhou et al, 2001) . Additionally, PanK4 has been shown to regulate Pkm2 activity affecting glucose metabolism (Li et al, 2005) . There have been several phospho-serine, threonine, and tyrosine sites identified within PanK4, the role of each one has yet to be determined.

Synonyms

DKFZp547M242 antibody, FLJ10782 antibody, hPanK 4 antibody, hPanK4 antibody, PANK 4 antibody, Pantothenate kinase 4 antibody, Pantothenic acid kinase antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

PANK4

NCBI Gene ID

269614

UniProt

Q80YV4

Modification Site

Thr63

Host

Rabbit

Reactivity

Mouse

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr63 of mouse PanK4, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Mouse

Target

PanK4 (Thr63)

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB

Concentration

Lot Dependent

Format

Antigen Affinity Purified from Pooled Serum

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Phosphorylated

Molecular Weight

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.