Anti-Metabotropic Glutamate Receptor 7 (Ser862) Antibody

Our Anti-Metabotropic Glutamate Receptor 7 (Ser862) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat Metabotropic Glutamate Receptor 7 (Ser862) and is antigen affinity purified. It is great for use in WB.

Product Specifications

Background

Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001) . The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of Ser-862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008) .

Synonyms

FLJ40498 antibody, GLUR7 antibody, Glutamate receptor metabotropic 7 antibody, GPRC1G antibody, GRM7 antibody, GRM7_HUMAN antibody, Metabotropic glutamate receptor 7 antibody, MGLU7 antibody, mGluR7 antibody, OTTHUMP00000206961 antibody, OTTHUMP00000214674 antibody, OTTHUMP00000214675 antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

GRM7

NCBI Gene ID

81672

UniProt

P35400

Modification Site

Ser862

Host

Rabbit

Reactivity

Mouse and Rat

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser862 of rat mGluR7, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Rat

Target

Metabotropic Glutamate Receptor 7 (Ser862)

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB

Concentration

Lot Dependent

Format

Antigen Affinity Purified from Pooled Serum

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Phosphorylated

Molecular Weight

102

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

WB Dilution

1:1000

Specificity

Specific for the ~102 kDa mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.