Anti-Metabotropic Glutamate Receptor 1a Antibody

Our Anti-Metabotropic Glutamate Receptor 1a primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat Metabotropic Glutamate Receptor 1a and is antigen affinity purified. It is great for use in WB, IHC.

Product Specifications

Background

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001) . Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003) .

Synonyms

Glutamate receptor metabotropic 1 antibody, GPRC1A antibody, GRM1 alpha antibody, GRM1 antibody, GRM1_HUMAN antibody, Metabotropic glutamate receptor 1 antibody, MGLU1 antibody, mGluR1 antibody, SCAR13 antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

GRM1

NCBI Gene ID

24414

UniProt

P23385

Host

Rabbit

Reactivity

Mouse and Rat

Immunogen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat mGluR1a, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Rat

Target

Metabotropic Glutamate Receptor 1a

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB, IHC

Concentration

Lot Dependent

Format

Antigen Affinity Purified

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Molecular Weight

125/250

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

IHC Dilution

1:500

WB Dilution

1:1000

Specificity

Specific for endogenous levels of the ~125 kDa monomer and the ~250 kDa mGluR1a dimer. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.