Anti-MeCP2 Antibody

Our Anti-MeCP2 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat MeCP2 and is Protein G purified. It is great for use in WB, IHC, ICC.

Product Specifications

Background

MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998) . Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999) . RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Synonyms

AUTSX 3 antibody, AUTSX3 antibody, DKFZp686A24160 antibody, Mbd 5 antibody, Mbd5 antibody, MECP 2 antibody, MeCP 2 protein antibody, MeCP-2 protein antibody, Mecp2 antibody, MECP2_HUMAN antibody, Methyl CpG binding protein 2 (Rett syndrome) antibody, Methyl CpG binding protein 2 antibody, Methyl-CpG-binding protein 2 antibody, MRX 16 antibody, MRX 79 antibody, MRX16 antibody, MRX79 antibody, MRXS 13 antibody, MRXS13 antibody, MRXSL antibody, PPMX antibody, RS antibody, RTS antibody, RTT antibody, WBP 10 antibody, WBP10 antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

MECP2

NCBI Gene ID

4204

UniProt

P51608

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Full length human recombinant MeCP2

Immunogen Type

Human

Target

MeCP2

Clonality

Monoclonal

Clone

5H12

Conjugation

Unconjugated

Applications

ELISA, WB, IHC, ICC

Concentration

1 mg/mL

Format

Protein G Purified

Form

Liquid

Buffer

PBS + 50% glycerol and 5 mM NaN3

Molecular Weight

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

IHC Dilution

1:500-1:5000

WB Dilution

1:2000

Specificity

Specific for endogenous levels of the MeCP2 protein. Due to usually high charge, the protein runs at ~75 kDa in SDS-PAGE of mouse brain lysates.

Formulation

Protein G purified culture supernatant

ICC Dilution

1:1000-1:5000

Quality Control

Western blots performed on each lot.

Isotype

IgG2b

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