Anti-Lamin A/C Antibody
Our Anti-Lamin A/C primary antibody from PhosphoSolutions is mouse monoclonal. It detects human Lamin A/C and is Protein G purified. It is great for use in WB, IHC, ICC.
Product Specifications
Background
Lamins A and C are nuclear structural proteins that are part of the intermediate filament family and coded for by the same gene (LMNA) . Lamins A and C are nearly identical except for their carboxy termini (McKeon et al., 1986) . Mutations in the gene encoding lamins A/C have been shown to cause a variety of diseases including autosomal dominant Emery-Dreifuss muscular dystrophy (Bonne et al., 1995), autosomal dominant limbgirdle muscular dystrophy (Muchir et al., 2000) and Charcot-Marie-Tooth disorder type 2 (De Sandre-Giavonnoli et al., 2002) .
Synonyms
70 kDa lamin antibody, Cardiomyopathy dilated 1A (autosomal dominant) antibody, CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, Lamin A antibody, Lamin A/C antibody, Lamin A/C like 1 antibody, Lamin antibody, Lamin C antibody, Lamin-A/C antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, Limb girdle muscular dystrophy 1B (autosomal dominant) antibody, LMN 1 antibody, LMN A antibody, LMN C antibody, LMN1 antibody, LMNA antibody, LMNA_HUMAN antibody, LMNC antibody, LMNL1 antibody, Prelamin A/C antibody, PRO1 antibody, Renal carcinoma antigen NY REN 32 antibody, Renal carcinoma antigen NY-REN-32 antibody, Renal carcinoma antigen NYREN32 antibody
Other Statements
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Gene Name
LMNA
NCBI Gene ID
4000
UniProt
P02545
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full length human lamin C expressed in and purified from E. Coli.
Immunogen Type
Human
Target
Lamin A/C
Clonality
Monoclonal
Clone
4C4
Conjugation
Unconjugated
Applications
ELISA, WB, IHC, ICC
Concentration
1 mg/mL
Format
Protein G Purified
Form
Liquid
Buffer
PBS + 10 mM NaN3.
Molecular Weight
64, 74
Shipping Conditions
Blue Ice
Storage Conditions
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
IHC Dilution
1:1000
WB Dilution
1:5000
Specificity
Specific for endogenous levels of the ~64 kDa and ~74 kDa lamin A and C proteins.
Formulation
Protein G purified culture supernatant
ICC Dilution
1:1000
Quality Control
Western blots performed on each lot.
Isotype
IgG1
Curated Selection
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