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Anti-Lamin A/C Antibody

Our Anti-Lamin A/C primary antibody from PhosphoSolutions is mouse monoclonal. It detects human Lamin A/C and is Protein G purified. It is great for use in WB, IHC, ICC.

Product Specifications

Background

Lamins A and C are nuclear structural proteins that are part of the intermediate filament family and coded for by the same gene (LMNA) . Lamins A and C are nearly identical except for their carboxy termini (McKeon et al., 1986) . Mutations in the gene encoding lamins A/C have been shown to cause a variety of diseases including autosomal dominant Emery-Dreifuss muscular dystrophy (Bonne et al., 1995), autosomal dominant limbgirdle muscular dystrophy (Muchir et al., 2000) and Charcot-Marie-Tooth disorder type 2 (De Sandre-Giavonnoli et al., 2002) .

Synonyms

70 kDa lamin antibody, Cardiomyopathy dilated 1A (autosomal dominant) antibody, CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, Lamin A antibody, Lamin A/C antibody, Lamin A/C like 1 antibody, Lamin antibody, Lamin C antibody, Lamin-A/C antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, Limb girdle muscular dystrophy 1B (autosomal dominant) antibody, LMN 1 antibody, LMN A antibody, LMN C antibody, LMN1 antibody, LMNA antibody, LMNA_HUMAN antibody, LMNC antibody, LMNL1 antibody, Prelamin A/C antibody, PRO1 antibody, Renal carcinoma antigen NY REN 32 antibody, Renal carcinoma antigen NY-REN-32 antibody, Renal carcinoma antigen NYREN32 antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

LMNA

NCBI Gene ID

4000

UniProt

P02545

Host

Mouse

Reactivity

Human

Immunogen

Recombinant full length human lamin C expressed in and purified from E. Coli.

Immunogen Type

Human

Target

Lamin A/C

Clonality

Monoclonal

Clone

4C4

Conjugation

Unconjugated

Applications

ELISA, WB, IHC, ICC

Concentration

1 mg/mL

Format

Protein G Purified

Form

Liquid

Buffer

PBS + 10 mM NaN3.

Molecular Weight

64, 74

Shipping Conditions

Blue Ice

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

IHC Dilution

1:1000

WB Dilution

1:5000

Specificity

Specific for endogenous levels of the ~64 kDa and ~74 kDa lamin A and C proteins.

Formulation

Protein G purified culture supernatant

ICC Dilution

1:1000

Quality Control

Western blots performed on each lot.

Isotype

IgG1

Frequently Asked Questions

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