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Anti-GluR2/3 Antibody

Our Anti-GluR2/3 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat GluR2/3 and is antigen affinity purified from pooled serum. It is great for use in WB.

Product Specifications

Background

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR) . The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994) . The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003; Seidenman et al., 2003; Chung et al., 2003; Yan et al., 2002) .

Synonyms

AMPA selective glutamate receptor 2 antibody, AMPA selective glutamate receptor 3 antibody, GluR K2 antibody, GluR K3 antibody, GLURB antibody, GLURC antibody, GLUTAMATE RECEPTOR 2 antibody, GLUTAMATE RECEPTOR 3 antibody, Glutamate receptor ionotropic AMPA 2 antibody, Glutamate receptor ionotropic AMPA 3 antibody, GRIA2 antibody, GRIA3 antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

GRIA2/3

NCBI Gene ID

29627

UniProt

P19491

Host

Rabbit

Reactivity

Rat

Immunogen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Rat

Target

GluR2/3

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB

Concentration

Lot Dependent

Format

Antigen Affinity Purified from Pooled Serum

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Molecular Weight

100

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

WB Dilution

1:1000

Specificity

Specific for endogenous levels of the ~100 kDa GluR2/3 protein.

Formulation

Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

Quality Control

Western blots performed on each lot.

Species

Chicken, Human, Mouse, Zebrafish

Isotype

IgG

Curated Selection

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