Anti-GABA Transporter (GAT) 1 Antibody

Our Anti-GABA Transporter (GAT) 1 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, non-human primate, and rat GABA Transporter (GAT) 1 and is affinity purified. It is great for use in WB, IHC.

Product Specifications

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995) . GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003) .

Synonyms

GABATHG antibody, GABATR antibody, GABT 1 antibody, GABT1 antibody, GAT-1 antibody, GAT1 antibody, SC6A1_HUMAN antibody, Slc6a1 antibody, Sodium and chloride dependent GABA transporter 1 antibody, Sodium- and chloride-dependent GABA transporter 1 antibody, Solute carrier family 6 (neurotransmitter transporter GABA) member 1 antibody, Solute carrier family 6 member 1 antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

SLC6A1

NCBI Gene ID

79212

UniProt

P23978

Host

Rabbit

Reactivity

Human, Mouse, Non-Human Primate, and Rat

Immunogen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAT1, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Rat

Target

GABA Transporter (GAT) 1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB, IHC

Concentration

Lot Dependent

Format

Affinity Purified

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Molecular Weight

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

IHC Dilution

1:100-1:1000

WB Dilution

1:1000

Specificity

Specific for endogenous levels of the ~67 kDa GAT-1 protein. Immunolabeling is blocked by pre-adsorption of antibody with the peptide used to generate the antibody.