Anti-GABAB Receptor (Ser923), R1-Subunit Antibody

Our Anti-GABAB Receptor (Ser923), R1-Subunit rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GABAB Receptor (Ser923), R1-Subunit and is antigen affinity purified from pooled serum. It is great for use in WB.

Product Specifications

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABA-B receptor effector coupling (Couve et al., 2004) . Phosphorylation of Ser-923 is thought to be important in the regulation of GABA-B receptor function.

Synonyms

DJ271M21.1.1 antibody, dJ271M21.1.2 antibody, FLJ92613 antibody, GABA-B receptor 1 antibody, GABA-B-R1 antibody, GABA-BR1 antibody, GABAB R1 antibody, GABAB subunit 1c antibody, GABABR1 antibody, GABBR1 3 antibody, GABBR1 antibody, GABR1_HUMAN antibody, Gamma aminobutyric acid (GABA) B receptor 1 antibody, Gamma-aminobutyric acid type B receptor subunit 1 antibody, Gb1 antibody, GPRC3A antibody, Seven transmembrane helix receptor antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

GABBR1

NCBI Gene ID

81657

UniProt

Q9Z0U4

Modification Site

Ser923

Host

Rabbit

Reactivity

Mouse and Rat

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 of the R1-subunit of rat GABAB receptor, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Rat

Target

GABAB Receptor (Ser923), R1-Subunit

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB

Concentration

Lot Dependent

Format

Antigen Affinity Purified from Pooled Serum

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Phosphorylated

Molecular Weight

102

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

WB Dilution

1:1000

Specificity

Specific for endogenous levels of the ~102 kDa GABAB R1 phosphorylated at Ser923. Immunolabeling is completely eliminated by treatment with λ-phosphatase.