Anti-Calcitonin Gene Related Peptide (CGRP) Antibody

Our Anti-Calcitonin Gene Related Peptide (CGRP) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human and rat Calcitonin Gene Related Peptide (CGRP) and is Protein G purified. It is great for use in ICC.

Product Specifications

Background

Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985) . CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003) . CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993) .

Synonyms

Calcitonin/calcitonin related polypeptide alpha antibody, Alpha type CGRP antibody, Beta type CGRP antibody, CALC1 antibody, CALC2 antibody, CALCA antibody, CALCB antibody, Calcitonin 1 antibody, Calcitonin 2 antibody, Calcitonin gene related peptide I antibody, Calcitonin gene related peptide II antibody, Calcitonin related polypeptide alpha antibody, Calcitonin related polypeptide beta antibody, CGRP antibody, CGRP I antibody, CGRP II antibody, CGRP1 antibody, CGRP2 antibody, CT antibody, Katacalcin antibody, KC antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

CALCA

NCBI Gene ID

24241

UniProt

P01256

Host

Mouse

Reactivity

Human and Rat

Immunogen

Purified rat alpha-CGRP.

Immunogen Type

Rat

Target

Calcitonin Gene Related Peptide (CGRP)

Clonality

Monoclonal

Clone

4901

Conjugation

Unconjugated

Applications

ELISA, ICC

Concentration

1 mg/ml

Format

Protein G Purified

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

WB Dilution

Not recommended

Specificity

Specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP) . Suggested positive controls are dorsal root ganglia, pancreas and gut.