Anti-Amyloid Precursor Protein Antibody

Our Anti-Amyloid Precursor Protein rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat Amyloid Precursor Protein and is antigen affinity purified from pooled serum. It is great for use in WB.

Product Specifications

Background

A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003) . The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001) .

Synonyms

A4 amyloid protein antibody, A4_HUMAN antibody, AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, AICD-50 antibody, AICD-57 antibody, AICD-59 antibody, AID (50) antibody, AID (57) antibody, AID (59) antibody, Alzheimer disease amyloid protein antibody, Amyloid beta (A4) precursor protein antibody, Amyloid beta A4 protein antibody, Amyloid beta protein antibody, Amyloid intracellular domain 50 antibody, Amyloid intracellular domain 57 antibody, Amyloid intracellular domain 59 antibody, Amyloid precursor protein antibody, APP antibody, APPI antibody, Beta amyloid peptide antibody, Beta-amyloid precursor protein antibody, Beta-APP40 antibody, Beta-APP42 antibody, C31 antibody, Cerebral vascular amyloid peptide antibody, CTFgamma antibody, CVAP antibody, Gamma-CTF (50) antibody, Gamma-CTF (57) antibody, Gamma-CTF (59) antibody, peptidase nexin II antibody, PN 2 antibody, PN II antibody, PN-II antibody, PN2 antibody, PreA4 antibody, Protease nexin II antibody, Protease nexin-II antibody, S-APP-alpha antibody, S-APP-beta antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

APP

NCBI Gene ID

54226

UniProt

P08592

Host

Rabbit

Reactivity

Mouse and Rat

Immunogen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat APP, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Rat

Target

Amyloid Precursor Protein

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB

Concentration

Lot Dependent

Format

Antigen Affinity Purified from Pooled Serum

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Molecular Weight

115

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

WB Dilution

1:1000

Specificity

Specific for endogenous levels of the ~115 kDa APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen.