Anti-Mu Opioid Receptor Antibody

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that activate intracellular signaling cascades and undergo endocytosis, recycling, or degradation upon stimulation. The (mu) m-, delta (d) and kappa (k) opioid receptors are GPCRs of the nervous system, which control pain, stress, and addictive behaviors. The mu opioid receptor (MOR-1) is a high-affinity receptor for enkephalins and beta-endorphins with low affinity for dynorphins. The opiate alkaloids morphine and codeine bind to MOR-1.

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Reacts with the C-terminal region of the human, mouse and rat MOR-1 protein. The antibody may detect dimmers or trimers on a Western blot as heterodimerization and homodimerization is common with the opioid receptors; however the monomer should be the dominant MOR-1 band at about 46 kDa.