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Anti-LRRK2 Antibody

Our LRRK2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human LRRK2 and is antigen affinity purified. It is great for use in WB.

Product Specifications

Background

The novel LRRK2 gene (also known as PARK8), is responsible for up to 6% of all autosomal dominant Parkinson’s disease (PD) . LRRK2 missense mutations segregate with PARK8-linked PD and are implicated in other neurodegenerative diseases involving alpha-synuclein and tau pathology.

Synonyms

PARK8; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

LRRK2

UniProt

Q5S007

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids from an internal sequence of the human LRRK2 protein

Immunogen Type

Human

Target

LRRK2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB

Format

Antigen Affinity Purified

Form

Liquid

Buffer

PBS + 0.02% NaN3

Shipping Conditions

Blue Ice

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

WB Dilution

1:500-1:1000

Specificity

Reacts with an internal region of the 260 kDa human LRRK2 protein. 87% sequence identity in mouse and rat.

Formulation

Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

Quality Control

Western blots performed on each lot.

Isotype

IgG

Curated Selection

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