Anti-ZNRF2 Antibody

Our ZNRF2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human ZNRF2 and is antigen affinity purified. It is great for use in WB.

Product Specifications

Background

Protein ubiquitination has been implicated recently in neural development, plasticity, and degeneration. ZNRF1/nin283, is a protein with a unique, evolutionarily conserved C-terminal domain containing a juxtaposed zinc finger/RING finger combination. ZNRF2, is another novel member of the family of ZNRF E3 ubiquitin ligases. Both ZNRF1 and ZNRF2 have E3 ubiquitin ligase activity and are highly expressed in the nervous system, particularly during development. In neurons, ZNRF proteins are located in different compartments within the presynaptic terminal: ZNRF1 is associated with synaptic vesicle membranes, whereas ZNRF2 is present in presynaptic plasma membranes. Data suggest that ZNRF proteins play a role in the establishment and maintenance of neuronal transmission and plasticity via their ubiquitin ligase activity.

Synonyms

E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2, RING-type E3 ubiquitin transferase

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

ZNRF2

UniProt

Q8NHG8

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids from an internal region of human DPP10 protein

Immunogen Type

Human

Target

ZNRF2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Format

Antigen Affinity Purified

Form

Liquid

Buffer

PBS + 0.02% NaN3

Shipping Conditions

Blue Ice

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.