Anti-PUMA Antibody

Our PUMA rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human PUMA and is antigen affinity purified. It is great for use in WB.

Product Specifications

Background

A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Synonyms

BBC3, Bcl-2-binding component 3, isoforms 1/2, JFY1, p53 up-regulated modulator of apoptosis

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

BBC3

UniProt

Q9BXH1

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids from a sequence found in the exon-3-encoded region in the human PUMA-a and PUMA-b forms of the protein.

Immunogen Type

Human

Target

PUMA

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Format

Antigen Affinity Purified

Form

Liquid

Buffer

PBS + 0.02% NaN3

Shipping Conditions

Blue Ice

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.