Anti-FBXW7 (hCdc4) Antibody
Our FBXW7 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human FBXW7 and is antigen affinity purified. It is great for use in WB.
Product Specifications
Background
Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of malignancies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.
Synonyms
Cdc4, FBXW7, Archipelago, AGO, F box and WD 40 domain protein 7, FBW7, SEL10
Other Statements
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Gene Name
FBXW7
UniProt
Q969H0
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide corresponding to amino acids from the N-terminal region of human Cdc4 protein
Immunogen Type
Human
Target
FBXW7
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Format
Antigen Affinity Purified
Form
Liquid
Buffer
PBS + 0.02% NaN3
Molecular Weight
69
Shipping Conditions
Blue Ice
Storage Conditions
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
WB Dilution
1:500-1:1000
Specificity
Reacts with the N terminus of the 69 kDa isoform of the hCdc4 protein
Formulation
Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Quality Control
Western blots performed on each lot.
Isotype
IgG
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