Anti-FBXW7 (hCdc4) Antibody

Our FBXW7 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human FBXW7 and is antigen affinity purified. It is great for use in WB.

Product Specifications

Background

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of malignancies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.

Synonyms

Cdc4, FBXW7, Archipelago, AGO, F box and WD 40 domain protein 7, FBW7, SEL10

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

FBXW7

UniProt

Q969H0

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human Cdc4 protein

Immunogen Type

Human

Target

FBXW7

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Format

Antigen Affinity Purified

Form

Liquid

Buffer

PBS + 0.02% NaN3

Molecular Weight

Shipping Conditions

Blue Ice

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.