Anti-FLASH (C-terminus) Antibody

Our FLASH rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human FLASH and is antigen affinity purified. It is great for use in WB.

Product Specifications

Background

Fas is a cell-surface receptor molecule that relays apoptotic (cell death) signals into cells. When Fas is activated by binding of its ligand, the proteolytic protein caspase-8 is recruited to a signalling complex known as DISC by binding to a Fas-associated adapter protein. A new protein, FLASH, contains a motif with oligomerizing activity whose sequence is similar to that of the Caenorhabditis elegans protein CED-4, and another domain (DRD domain) that interacts with a death-effector domain in caspase-8 or in the adapter protein. FLASH is likely a component of the DISC signalling complex and is necessary for the activation of caspase-8 in Fas-mediated apoptosis.

Synonyms

CASP8-associated protein 2, CASP8AP, FLICE-associated huge protein, CED4, RIP25

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

CASP8AP2

UniProt

Q9UKL3

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids from the C-terminal region of human FLASH protein

Immunogen Type

Human

Target

FLASH

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Format

Antigen Affinity Purified

Form

Liquid

Buffer

PBS + 0.02% NaN3

Shipping Conditions

Blue Ice

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.