Anti-M6PR (2G11) Recombinant Chicken Chimeric mAb

The cation-independent mannose-6-phosphate receptor (CI-M6PR), also known as the insulin-like growth factor 2 receptor (IGF2R), is a large type I transmembrane glycoprotein of ~300 kDa that mediates trafficking of lysosomal hydrolases. CI-M6PR recognizes mannose-6-phosphate (M6P) tags on newly synthesized enzymes and facilitates their transport from the trans-Golgi network to endosomes, ensuring proper lysosomal function. In addition to its canonical role in lysosomal enzyme sorting, CI-M6PR regulates extracellular signaling by binding and internalizing insulin-like growth factor 2 (IGF2), thereby modulating cell growth and proliferation. Loss or dysregulation of CI-M6PR expression has been associated with impaired lysosomal biogenesis, altered growth factor signaling, and tumorigenesis, highlighting its dual role in both intracellular trafficking and growth regulation. Because of its involvement in cancer biology and lysosomal storage disorders, CI-M6PR is an important marker and functional regulator in both health and disease.

Our Anti-M6PR chicken recombinant primary antibody from Aves Labs is produced in-house from hybridoma clone 2G11. It detects bovine, human, and non-human primate M6PR, and is purified by affinity chromatography. It is great for use in IHC, ICC, IP.

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone 2G11 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone 2G11 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.