ML372

ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1].

Product Specifications

CAS Number

[1331745-61-9]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml372.html

Purity

99.17

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1CCN(C2=NC=C(C3=CC=C(OCCCO4)C4=C3)S2)CC1)O

Molecular Formula

C18H20N2O4S

Molecular Weight

360.43

References & Citations

[1]Mahlet B Abera, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. JCI Insight. 2016 Nov 17;1 (19) :e88427.