Rb (phospho-Ser807/811) rabbit pAb
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Product Name Alternative
Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
UniProt
P06400
Swiss Prot
P06400
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized phosho peptide around human Rb (Ser807 and 811)
Target
Rb
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
106kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
106kD
Fragment
IgG
Subcellular Location
Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
Other Product Names
Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
Gene ID (Human)
5925
Available Sizes
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