Cyclo(L-Phe-L-Pro)
Product Specifications
UNSPSC Description
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].
Target Antigen
Fungal; IFNAR; Reactive Oxygen Species
Type
Peptides
Related Pathways
Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Infection
Assay Protocol
https://www.medchemexpress.com/cyclo-l-phe-l-pro.html
Purity
99.91
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]1CC2=CC=CC=C2)[C@@](CCC3)([H])N3C1=O
Molecular Weight
244.294
References & Citations
[1]Katrin Ström, et al. <i>Lactobacillus plantarum</i> MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo(L-Phe-L-Pro) and Cyclo(L-Phe-trans-4-OH-L-Pro) and 3-Phenyllactic Acid. Appl Environ Microbiol. 2002 Sep;68(9):4322-7.|[2]Wooseong Lee, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.|[3]Keyong Ho Lee, et al. Radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lung. J Microbiol Biotechnol. 2008 Feb;18(2):369-76.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1934A/Cyclo-L-Phe-L-Pro-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1934A/Cyclo-L-Phe-L-Pro-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3705-26-8
Available Sizes
Curated Selection
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