CB-5339
CB-5339 is an oral activity potent p97 inhibitor with an IC50 [1]. CB-5339 extracted from WO2015109285A1 compound FF07.
Product Specifications
CAS Number
1863952-15-1
UNSPSC
12352005
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cb-5339.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(CCCN5)C5=N3)N
Molecular Formula
C24H24N6O
Molecular Weight
412.49
References & Citations
[1]David Wustrow, et al. FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX. WO2015109285A1.|[2]Roux B, et.al. Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor. Sci Transl Med. 2021 Mar 31;13 (587) :eabg1168.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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