Ac-WEHD-AFC (TFA)

Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation[1].

Product Specifications

UNSPSC

12352209

Target

Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-wehd-afc-tfa.html

Purity

98.84

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC3=CNC4=CC=CC=C34)=O)=O)CC5=CN=CN5)=O)=O)=CC1=O)F.OC(C(F)(F)F)=O

Molecular Formula

C40H38F6N8O13

Molecular Weight

952.77

References & Citations

[1]Katherine Labbé, et al. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity. 2011 Dec 23;35 (6) :897-907.