TAT-14

TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1[1].

Product Specifications

CAS Number

[1362661-34-4]

UNSPSC

12352209

Target

Keap1-Nrf2

Type

Peptides

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tat-14.html

Purity

99.71

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC(N)=O)=O)CC(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)=O)CCC(O)=O)=O)=O)CC(C)C)(=O)N3[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)[C@H](CC)C)=O)CCC3

Molecular Formula

C137H230N48O39

Molecular Weight

3173.59

References & Citations

[1]Richard Steel, et al. Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction. ACS Med Chem Lett. 2012 May 10;3 (5) :407-410.