Cyanine7 DBCO

Cyanine7 DBCO (Cy7 DBCO) is a near-infrared fluorescent dye and an efficient bio-orthogonal quencher. Cyanine7 DBCO is formed by covalent connection of the near-infrared fluorescent dye Cy7 and the dibenzocyclooctyne (DBCO) functional group. After reacting with N3-Cy5-COOH, the fluorescence of Cy5 decreases by 90% within 90 minutes, and rapid signal attenuation can be observed within 2-5 minutes. Cyanine7 DBCO can be used for the study of deep tissue imaging and receptor-targeted therapeutic strategies[1][2].

Product Specifications

CAS Number

[2692677-77-1]

Product Name Alternative

Cy7 DBCO

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cyanine7-dbco.html

Purity

98.0

Solubility

DMSO : 4.98 mg/mL (ultrasonic; warming)

Smiles

O=C(CCCCC[N+]1=C(/C=C/C2=C/C(CCC2)=C/C=C3N(C)C4=C(C\3(C)C)C=CC=C4)C(C)(C)C5=C1C=CC=C5)NCCCCCC(N6C7=C(C#CC8=C(C6)C=CC=C8)C=CC=C7)=O.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

Molecular Formula

C58H65F6N4O2P

Molecular Weight

995.13

References & Citations

[1]R. Islam, et al. Design and Synthesis of Core–Shell Microgels with One-Step Clickable Crosslinked Cores and Ultralow Crosslinked Shells. Macromol Chem Phys. 2020, 221, 2000156.|[2]van der Wal S, et al. Bioorthogonally Applicable Fluorescence Deactivation Strategy for Receptor Kinetics Study and Theranostic Pretargeting Approaches. Chembiochem. 2018 Jun 4;19 (16) :1758–65.