ALC-0315

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine[1].

Product Specifications

CAS Number

[2036272-55-4]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Liposome; SARS-CoV

Type

Oligonucleotides

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/alc-0315.html

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O

Molecular Formula

C48H95NO5

Molecular Weight

766.27

Precautions

H315, H319

References & Citations

[1]Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021;29 (3) :898-900.|[2]Ferraresso F, Strilchuk AW, Juang LJ, Poole LG, Luyendyk JP, Kastrup CJ. Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells. Mol Pharm. 2022;19 (7) :2175-2182.