Myristyl nicotinate

Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].

Product Specifications

CAS Number

[273203-62-6]

Product Name Alternative

Tetradecyl nicotinate

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/myristyl-nicotinate.html

Concentration

10mM

Purity

99.40

Solubility

DMSO : 9.62 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN=C1)OCCCCCCCCCCCCCC

Molecular Formula

C20H33NO2

Molecular Weight

319.48

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Catz P, et al. Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829 (1-2) :123-35.|[2]Jacobson MK, et al. Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage. Exp Dermatol. 2007 Nov;16 (11) :927-35.