RFRP-3 (human) (TFA)

RFRP-3 (Neuropeptide VF (124-131) ) (human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3 (human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].

Product Specifications

Product Name Alternative

Neuropeptide VF (124-131) (human) (TFA) ; Neuropeptide NPVF (human) (TFA)

UNSPSC

12352209

Target

Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rfrp-3-human-tfa.html

Solubility

10 mM in DMSO

Smiles

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H]2N(C([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H]3N(C([C@H](C(C)C)N)=O)CCC3)=O)=O)=O)CCC2)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C47H73F3N14O12

Molecular Weight

1083.16

References & Citations

[1] Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology