1- (4-Methoxyphenyl) -3-methyl-1H-pyrazol-5 (4H) -one

1- (4-Methoxyphenyl) -3-methyl-1H-pyrazol-5 (4H) -one (Compound 2) has antiprion activity in ScN2a and F3 cells with IC50 values of 13 nM and 25 nM, respectively[1].

Product Specifications

CAS Number

[60798-06-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Prion Protein; Transmembrane Glycoprotein

Type

Reference compound

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-4-methoxyphenyl-3-methyl-1h-pyrazol-5-4h-one.html

Purity

99.54

Smiles

O=C1CC(C)=NN1C2=CC=C(OC)C=C2

Molecular Formula

C11H12N2O2

Molecular Weight

204.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation. J Med Chem. 2007 Oct 18;50 (21) :5053-6.