PARP Mouse Mouse Monoclonal Antibody
Product Specifications
Background
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.
Product Name Alternative
COBA2; COL11A2; Collagen alpha-2 (XI) chain; collagen, type XI, alpha 2; DFNA13
Gene Name
PARP Mouse
Gene ID
1302
Swiss Prot
P13942
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB
Purification
Affinity Purification
Dilution
WB 1:1000-1:3000
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Modification
Unmodified
Molecular Weight
116kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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