CaMKII (Phospho-Thr 286) Mouse Monoclonal Antibody

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/ threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated α , β , γ andδ , which may or may not be coexpressed in the same tissue types. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.

Calcium/calmodulin dependent protein kinase II alpha antibody</br> Calcium/calmodulin dependent protein kinase II beta antibody</br> Calcium/calmodulin dependent protein kinase II delta antibody</br> Calcium/calmodulin dependent protein kinase II gamma antibody</br> Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody</br> CaM kinase II alpha antibody</br> CaM kinase II antibody</br> CaM kinase II beta antibody</br> CaM kinase II delta antibody</br> CaM kinase II gamma antibody</br> CaM kinase II subunit alpha antibody</br> CaMK-II subunit alpha antibody</br> CAMK2 antibody</br> Camk2a antibody</br> CAMK2B antibody</br> CAMK2D antibody</br> CAMK2G antibody</br> CAMKA antibody</br> KCC2A_HUMAN antibody</br>