SMAD6 Mouse Monoclonal Antibody
Product Specifications
Background
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Product Name Alternative
MADH6; MADH7; HsT17432; SMAD6
Gene Name
SMAD6
Gene ID
4091
Swiss Prot
O43541
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide.
Modification
Unmodified
Molecular Weight
53kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG1
Available Sizes
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