WDR5 Mouse Monoclonal Antibody
Product Specifications
Background
WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
Product Name Alternative
SWD3; BIG-3; WDR5
Gene Name
WDR5
Gene ID
11091
Swiss Prot
P61964
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
Unmodified
Molecular Weight
36.6kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG2b
Available Sizes
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