Lck Mouse Monoclonal Antibody
Product Specifications
Background
Lck (lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Product Name Alternative
YT16; p56lck; pp58lck
Gene Name
Lck
Gene ID
3932
Swiss Prot
P06239
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Field of Research
Jak-STAT signaling pathway
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide.
Modification
Unmodified
Molecular Weight
56kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG2a
Available Sizes
Curated Selection
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