EphB4 Mouse Monoclonal Antibody
Product Specifications
Background
EPH receptor B4 (EphB4), with 987-amino acid protein (about 108kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptor tyrosine kinases and their ligands, the ephrins, regulate numerous biological processes in developing and adult tissues and have been implicated in cancer progression and in pathological forms of angiogenesis. EphB4 acts as a negative regulator of blood vessel branching and vascular network formation, switching the vascularization program from sprouting angiogenesis to circumferential vessel growth. EphB4 and its ligand ephrinB2 express in several kinds of tumor cells and correlate with tumorigenesis. EphB4 is thus a potential candidate as a predictor of disease outcome in several kinds of tumor and as target for novel therapy.
Product Name Alternative
HTK; MYK1; TYRO11
Gene Name
EphB4
Gene ID
2050
Swiss Prot
P54760
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
IHC, ELISA
Purification
Affinity Purification
Dilution
IHC 1:200-1:1000, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG2a
Available Sizes
Curated Selection
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