KIF7 Mouse Monoclonal Antibody
Product Specifications
Background
Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164) . Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation . Involved in the regulation of epidermal differentiation and chondrocyte development .
Product Name Alternative
Kinesin like protein KIF7; EQYK340; kif7
Gene Name
KIF7
Gene ID
374654
Swiss Prot
Q2M1P5
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
IHC, ICC
Purification
Affinity Purification
Dilution
IHC 1:50-1:100, ICC 1:50-1:200
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Datasheet
https://assets.enkilife.com/files/monoclonal_antibody/AMM84937_EnkiLife_EN.pdf
Isotype
Mouse IgG1
Available Sizes
Curated Selection
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