MSX1 Mouse Monoclonal Antibody

Drosophila, muscle segment (msh) homolog 1, homeo domain encoding gene, inhibiting MYOD1 expression, highly expressed in dental mesenchyme during critical bud stage, involved in epithelial-mesenchymal signaling in many organs, and in the pathogenesis of cleft lip and palate, interacting with MSX2 in mouse limb bud patterning .This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition.Tissue specificity: Expressed in the developing nail bed mesenchyme.