STK11 Mouse Monoclonal Antibody

Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11, with two alternatively spliced isoforms, expressed in all tissues, strongly homolog of Xenopus early embryonic kinase 1 (XEEK1), tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis, mutated in sporadic testicular cancer, malignant melanomas and laryngeal tumors, playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.