Coelonin

Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2].

Product Specifications

CAS Number

[82344-82-9]

UNSPSC

12352005

Hazard Statement

H410

Target

Akt; Interleukin Related; NF-κB; PTEN; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/coelonin.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

OC(C=C1CC2)=CC(OC)=C1C3=C2C=C(O)C=C3

Molecular Formula

C15H14O3

Molecular Weight

242.27

Precautions

H410

References & Citations

[1]Jiang F, et al. Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism. Int J Mol Sci. 2019 Sep 8;20 (18) :4422.|[2]Cheng W, et al. Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM2.5-exposed human lung alveolar epithelial A549 cells. Eur J Pharmacol. 2021 Apr 5;896:173931.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Akt; IL-1; IL-6; NF-κB

Available Sizes

Curated Selection

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