IGF1R Mouse Monoclonal Antibody
Product Specifications
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Product Name Alternative
IGFR; CD221; IGFIR; JTK13
Gene Name
IGF1R
Gene ID
3480
Swiss Prot
P08069
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ELISA, FC
Field of Research
PI3K-Akt signaling pathway, Jak-STAT signaling pathway, Hippo signaling pathway
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:20000, FC 1:200-1:400
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide
Modification
Unmodified
Molecular Weight
154.8kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG2a
Available Sizes
Frequently Asked Questions
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