STAT3 Mouse Monoclonal Antibody
Product Specifications
Background
The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3
Product Name Alternative
APRF; HIES; FLJ20882; MGC16063; STAT3
Gene Name
STAT3
Gene ID
6774
Swiss Prot
P40763
Host
Mouse
Reactivity
Human, Mouse, Monkey
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC, ELISA
Field of Research
Jak-STAT signaling pathway
Purification
Affinity Purification
Dilution
WB 1:500-1:1000, IHC 1:200-1:1000, ICC 1:200-1:1000, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide.
Modification
Unmodified
Molecular Weight
88kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG1
Available Sizes
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