MAP4K4 Mouse Monoclonal Antibody
Product Specifications
Background
MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Product Name Alternative
HGK; NIK
Gene Name
MAP4K4
Gene ID
9448
Swiss Prot
O95819
Host
Mouse
Reactivity
Human, Mouse
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ICC, ELISA, FC
Field of Research
MAPK signaling pathway
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, ICC 1:50-1:200, ELISA 1:5000-1:20000, FC 1:200-1:400
Form
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
Unmodified
Molecular Weight
142kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG1
Available Sizes
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