MCM3 Mouse Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.
Product Name Alternative
HCC5; P1.h; RLFB; P1-MCM3
Gene Name
MCM3
Gene ID
4172
Swiss Prot
P25205
Host
Mouse
Reactivity
Human, Rat, Monkey
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC, FC
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, IHC 1:200-1:1000, ICC 1:50-1:200, FC 1:200-1:400
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide
Modification
Unmodified
Molecular Weight
91kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG1
Available Sizes
Curated Selection
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