CSNK2A2 Mouse Monoclonal Antibody
Product Specifications
Background
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB) . CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
Product Name Alternative
CK2A2; CSNK2A1; FLJ43934
Gene Name
CSNK2A2
Gene ID
1459
Swiss Prot
P19784
Host
Mouse
Reactivity
Human, Mouse, Rat, Monkey, Rabbit
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ELISA, FC
Field of Research
Apoptosis, Wnt signaling pathway
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:500, ELISA 1:5000-1:20000, FC 1:200-1:400
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide.
Modification
Unmodified
Molecular Weight
41.2kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG1
Available Sizes
Curated Selection
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