AIF Mouse Monoclonal Antibody
Product Specifications
Background
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10
Product Name Alternative
AIFM1; AIF; PDCD8; COXPD6; MGC111425
Gene Name
AIF
Gene ID
9131
Swiss Prot
O95831
Host
Mouse
Reactivity
Human, Mouse, Rat, , Monkey
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC, ELISA, FC
Field of Research
Apoptosis
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, IHC 1:200-1:1000, ICC 1:200-1:1000, ELISA 1:5000-1:20000, FC 1:200-1:400
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide.
Modification
Unmodified
Molecular Weight
67kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Datasheet
https://assets.enkilife.com/files/monoclonal_antibody/AMM81018_EnkiLife_EN.pdf
Isotype
Mouse IgG2b
Available Sizes
Curated Selection
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