Bax (2B12) Mouse Monoclonal Antibody
Product Specifications
Background
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.
Product Name Alternative
Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4
Gene Name
BAX
Gene ID
581
Swiss Prot
Q07812
Host
Mouse
Reactivity
Human, Monkey
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cell Biology
Purification
Affinity Purification
Dilution
WB 1:500-1:1000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Modification
Unmodified
Molecular Weight
Calculated MW: 21 kDa; Observed MW: 21 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG2a
Available Sizes
Curated Selection
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