2-Benzoxazolinone

2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2 (3H) -one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4].

Product Specifications

CAS Number

[59-49-4]

Product Name Alternative

2-Benzoxazolone; 1,3-Benzoxazol-2 (3H) -one; 2-Hydroxybenzoxazole

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-Benzoxazolinone.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 3.85 mg/mL (ultrasonic)

Smiles

O=C1OC2=CC=CC=C2N1

Molecular Formula

C7H5NO2

Molecular Weight

135.12

Precautions

H302+H312+H332

References & Citations

[1]Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60 (2) :187-8.|[2]Batish DR, et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus) . Plant Physiology and Biochemistry 44 (11-12) :819-27|[3]Krawiecka M, et al. Synthesis and biological activity of novel series of 1,3-benzoxazol-2 (3H) -one derivatives. Acta Pol Pharm. 2013 Mar-Apr;70 (2) :245-53.|[4]Miandji AM, et al. Synthesis and biological activities of some 1,3-benzoxazol-2 (3H) -one derivatives as anti-quorum sensing agents. Arzneimittelforschung. 2012 Jul;62 (7) :330-4.