JAK1 (7G6) Mouse Monoclonal Antibody

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1., domain:The FERM domain mediates interaction with JAKMIP1., function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL) -2 receptor., sequence caution:Translation N-terminally extended., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily., similarity:Contains 1 FERM domain., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH2 domain., subcellular location:Wholly intracellular, possibly membrane associated., subunit:Interacts with IL31RA, JAKMIP1 and SHB., tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.