IL-8 (13F8) Mouse Monoclonal Antibody

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008], function:IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8 (6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8 (5-77) has increased activity on neutrophil activation and IL-8 (7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8 (1-77), respectively., online information:Interleukin-8 entry, PTM:Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8 (1-77) is referred to as interleukin-8. IL-8 (6-77) is the most promiment form., similarity:Belongs to the intercrine alpha (chemokine CxC) family., subunit:Homodimer.

Cytokine-cytokine receptor interaction; Chemokine; Toll_Like; NOD-like receptor; RIG-I-like receptor; Epithelial cell signaling in Helicobacter pylori infection; Pathways in cancer; Bladder cancer