ABCB5 (11A2) Mouse Monoclonal Antibody

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]) .[supplied by OMIM, Mar 2008], caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data., caution:Was named ABCB1 by some authors., function:Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas., miscellaneous:Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells., similarity:Belongs to the ABC transporter family., similarity:Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily., similarity:Contains 1 ABC transmembrane type-1 domain., similarity:Contains 1 RRM (RNA recognition motif) domain., similarity:Contains 2 ABC transporter domains., subunit:Component of the U11/U12 snRNPs that are part of the U12-type spliceosome., tissue specificity:Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level) . Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues., tissue specificity:Expressed in heart, liver, skeletal muscle and pancreas.